Meikin is a conserved regulator of meiosis-I-specific kinetochore function

Article

关键词: SINGLE-DIVISION MEIOSIS;    PROTEIN PHOSPHATASE 2A;    CENTROMERIC COHESION;    HOMOLOGOUS CHROMOSOMES;    MONOPOLAR ATTACHMENT;    MAMMALIAN OOCYTES;    KINASE CDC5;    AURORA-B;    CLEAVAGE;    SEGREGATION;   

DOI  :  10.1038/nature14097

来源: SCIE

【 摘 要 】

The kinetochore is the crucial apparatus regulating chromosome segregation in mitosis and meiosis. Particularly in meiosis I, unlike in mitosis, sister kinetochores are captured by microtubules emanating from the same spindle pole (mono-orientation) and centromeric cohesion mediated by cohesin is protected in the following anaphase. Although meiotic kinetochore factors have been identified only in budding and fission yeasts, these molecules and their functions are thought to have diverged earlier. Therefore, a conserved mechanism for meiotic kinetochore regulation remains elusive. Here we have identified in mouse a meiosis-specific kinetochore factor that wetermed MEIKIN, which functions in meiosis I but not in meiosis II or mitosis. MEIKIN plays a crucial role in both mono-orientation and centromeric cohesion protection, partly by stabilizing the localization of the cohesin protector shugoshin. These functions are mediated mainly by the activity of Polo-like kinase PLK1, which is enriched to kinetochores in a MEIKIN-dependent manner. Our integrative analysis indicates that the long-awaited key regulator of meiotic kinetochore function is Meikin, which is conserved from yeasts to humans.

【 授权许可】

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