PROTEOLYSIS, PROTEASOMES AND ANTIGEN PRESENTATION

Review

关键词: MAJOR HISTOCOMPATIBILITY COMPLEX;    MOLECULAR-WEIGHT PROTEASE;    MULTICATALYTIC PROTEINASE COMPLEX;    RAT-LIVER;    SKELETAL-MUSCLE;    DEPENDENT PROTEOLYSIS;    RABBIT RETICULOCYTES;    26S COMPLEX;    T-CELLS;    UBIQUITIN;   

DOI  :  10.1038/357375a0

来源: SCIE

【 摘 要 】

Proteins presented to the immune system must first be cleaved to small peptides by intracellular proteinases. Proteasomes are proteolytic complexes that degrade cytosolic and nuclear proteins. These particles have been implicated in ATP-ubiquitin-dependent proteolysis and in the processing of intracellular antigens for cytolytic immune responses.

【 授权许可】

Free