Towards building a chromosome segregation machine

Review

关键词: SPINDLE ASSEMBLY CHECKPOINT;    BUDDING YEAST;    KINETOCHORE COMPLEX;    MITOTIC SPINDLE;    CENTROMERIC NUCLEOSOMES;    PERICENTRIC CHROMATIN;    STRUCTURAL INTEGRITY;    PLASMID PARTITION;    DISTINCT PATHWAYS;    MICROTUBULE TIPS;   

DOI  :  10.1038/nature08912

来源: SCIE

【 摘 要 】

All organisms, from bacteria to humans, face the daunting task of replicating, packaging and segregating up to two metres (about 6 x 10(9) base pairs) of DNA when each cell divides. This task is carried out up to a trillion times during the development of a human from a single fertilized cell. The strategy by which DNA is replicated is now well understood. But when it comes to packaging and segregating a genome, the mechanisms are only beginning to be understood and are often as variable as the organisms in which they are studied.

【 授权许可】

Free