Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

Article

关键词: SYSTEMATIC RNAI SCREEN;    LIFE-SPAN;    C. ELEGANS;    H3K4 TRIMETHYLATION;    STRESS RESISTANCE;    GENES;    COMPLEX;    METHYLATION;    DEMETHYLATION;    CHROMATIN;   

DOI  :  10.1038/nature10572

来源: SCIE

【 摘 要 】

Chromatin modifiers regulate lifespan in several organisms, raising the question of whether changes in chromatin states in the parental generation could be incompletely reprogrammed in the next generation and thereby affect the lifespan of descendants. The histone H3 lysine 4 trimethylation (H3K4me3) complex, composed of ASH-2, WDR-5 and the histone methyltransferase SET-2, regulates Caenorhabditis elegans lifespan. Here we show that deficiencies in the H3K4me3 chromatin modifiers ASH-2, WDR-5 or SET-2 in the parental generation extend the lifespan of descendants up until the third generation. The transgenerational inheritance of lifespan extension by members of the ASH-2 complex is dependent on the H3K4me3 demethylase RBR-2, and requires the presence of a functioning germline in the descendants. Transgenerational inheritance of lifespan is specific for the H3K4me3 methylation complex and is associated with epigenetic changes in gene expression. Thus, manipulation of specific chromatin modifiers only in parents can induce an epigenetic memory of longevity in descendants.

【 授权许可】

Free