Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

Article

关键词: HEMATOPOIETIC STEM-CELLS;    LINDAU TUMOR-SUPPRESSOR;    ENDOTHELIAL-CELLS;    FRACTURE REPAIR;    VASCULAR CONTRIBUTION;    ANGIOCRINE FACTORS;    PLASMA-MEMBRANE;    TRABECULAR BONE;    MARROW;    HYPOXIA;   

DOI  :  10.1038/nature13145

来源: SCIE

【 摘 要 】

The mammalian skeletal system harbours a hierarchical system of mesenchymal stem cells, osteoprogenitors and osteoblasts sustaining lifelong bone formation. Osteogenesis is indispensable for the homeostatic renewal of bone as well as regenerative fracture healing, but these processes frequently decline in ageing organisms, leading to loss of bone mass and increased fracture incidence. Evidence indicates that the growth of blood vessels in bone and osteogenesis are coupled, but relatively little is known about the underlying cellular and molecular mechanisms. Here we identify a new capillary subtype in the murine skeletal system with distinct morphological, molecular and functional properties. These vessels are found in specific locations, mediate growth of the bone vasculature, generate distinct metabolic and molecular microenvironments, maintain perivascular osteoprogenitors and couple angiogenesis to osteogenesis. The abundance of these vessels and associated osteoprogenitors was strongly reduced in bone from aged animals, and pharmacological reversal of this decline allowed the restoration of bone mass.

【 授权许可】

Free