The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms

Article

关键词: PLANARIAN STEM-CELLS;    REGENERATION;    CHECKPOINT;    ANEUPLOIDY;    REPAIR;    TIME;   

DOI  :  10.1038/nature25473

来源: SCIE

【 摘 要 】

The planarian Schmidtea mediterranea is an important model for stem cell research and regeneration, but adequate genome resources for this species have been lacking. Here we report a highly contiguous genome assembly of S. mediterranea, using long-read sequencing and a de novo assembler (MARVEL) enhanced for low-complexity reads. The S. mediterranea genome is highly polymorphic and repetitive, and harbours a novel class of giant retroelements. Furthermore, the genome assembly lacks a number of highly conserved genes, including critical components of the mitotic spindle assembly checkpoint, but planarians maintain checkpoint function. Our genome assembly provides a key model system resource that will be useful for studying regeneration and the evolutionary plasticity of core cell biological mechanisms.

【 授权许可】

Free