COMMON WEST AFRICAN HLA ANTIGENS ARE ASSOCIATED WITH PROTECTION FROM SEVERE MALARIA

Article

关键词: MAJOR HISTOCOMPATIBILITY COMPLEX;    FRAGMENT-LENGTH-POLYMORPHISM;    CD8+ T-CELLS;    MHC POLYMORPHISM;    MIXED ANCESTRY;    DQ ANTIGENS;    SELECTION;    SUBSTITUTION;    HAPLOTYPES;    ALLELES;   

DOI  :  10.1038/352595a0

来源: SCIE

【 摘 要 】

A large case-control study of malaria in West African children shows that a human leucocyte class I antigen (HLA-Bw53) and an HLA class II haplotype (DRB1*1302-DQB1*0501), common in West Africans but rare in other racial groups, are independently associated with protection from severe malaria. In this population they account for as great a reduction in disease incidence as the sickle-cell haemoglobin variant. These data support the hypothesis that the extraordinary polymorphism of major histocompatibility complex genes has evolved primarily through natural selection by infectious pathogens.

【 授权许可】

Free