ISOLATION AND CHARACTERIZATION OF THE INTRACELLULAR MHC CLASS-II COMPARTMENT

Article

关键词: HLA-DR MOLECULES;    INVARIANT CHAIN;    HISTOCOMPATIBILITY ANTIGENS;    TRANSFERRIN RECEPTOR;    SURFACE EXPRESSION;    FUSION INVITRO;    EARLY ENDOSOME;    CELL LINE;    TRANSPORT;    BINDING;   

DOI  :  10.1038/369120a0

来源: SCIE

【 摘 要 】

An intracellular compartment has been isolated to which MHC class II molecules are transported on their way to the plasma membrane. They arrive with an associated invariant chain which is then proteolytically processed while MHC class II molecules acquire antigenic peptide. These loaded class II molecules then leave the compartment devoid of invariant chain and bound for the plasma membrane. This compartment represents a new stage in the endocytic/lysosomal pathway.

【 授权许可】

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