Adipocytes as regulators of energy balance and glucose homeostasis

Review

关键词: INDUCED INSULIN-RESISTANCE;    FATTY-ACID OXIDATION;    ACTIVATED PROTEIN-KINASE;    BROWN ADIPOSE-TISSUE;    TOTAL-BODY FAT;    PPAR-GAMMA;    IN-VITRO;    CHEMOATTRACTANT PROTEIN-1;    ADIPONECTIN RECEPTORS;    TRANSCRIPTION FACTOR;   

DOI  :  10.1038/nature05483

来源: SCIE

【 摘 要 】

Adipocytes have been studied with increasing intensity as a result of the emergence of obesity as a serious public health problem and the realization that adipose tissue serves as an integrator of various physiological pathways. In particular, their role in calorie storage makes adipocytes well suited to the regulation of energy balance. Adipose tissue also serves as a crucial integrator of glucose homeostasis. Knowledge of adipocyte biology is therefore crucial for understanding the pathophysiological basis of obesity and metabolic diseases such as type 2 diabetes. Furthermore, the rational manipulation of adipose physiology is a promising avenue for therapy of these conditions.

【 授权许可】

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