The multilayered complexity of ceRNA crosstalk and competition

Review

关键词: RNA-BINDING PROTEIN;    LONG-NONCODING-RNA;    MICRORNA TARGET SITES;    MESSENGER-RNA;    HEPATOCELLULAR-CARCINOMA;    TRANSLATIONAL REPRESSION;    ENDOGENOUS MICRORNA;    TUMOR-SUPPRESSOR;    CIRCULAR RNAS;    IN-VIVO;   

DOI  :  10.1038/nature12986

来源: SCIE

【 摘 要 】

Recent reports have described an intricate interplay among diverse RNA species, including protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs, pseudogenes and circular RNAs. These RNA transcripts act as competing endogenous RNAs (ceRNAs) or natural microRNA sponges - they communicate with and co-regulate each other by competing for binding to shared microRNAs, a family of small non-coding RNAs that are important post-transcriptional regulators of gene expression. Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.

【 授权许可】

Free