The role of exercise and PGC1 alpha in inflammation and chronic disease

Article

关键词: NECROSIS-FACTOR-ALPHA;    TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA;    SKELETAL-MUSCLE;    PHYSICAL-ACTIVITY;    OXIDATIVE-PHOSPHORYLATION;    ANTIOXIDANT DEFENSE;    METABOLIC SYNDROME;    GENE-EXPRESSION;    PLASTICITY;    OBESITY;   

DOI  :  10.1038/nature07206

来源: SCIE

【 摘 要 】

Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1 alpha has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.

【 授权许可】

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