Activity-dependent neuronal signalling and autism spectrum disorder

Review

关键词: X MENTAL-RETARDATION;    DE-NOVO MUTATIONS;    DENDRITIC SPINE MORPHOLOGY;    LONG-TERM DEPRESSION;    FRAGILE-X;    MOUSE MODEL;    SYNAPTIC PLASTICITY;    BDNF TRANSCRIPTION;    RETT-SYNDROME;    FMRP PHOSPHORYLATION;   

DOI  :  10.1038/nature11860

来源: SCIE

【 摘 要 】

Neuronal activity induces the post-translational modification of synaptic molecules, promotes localized protein synthesis within dendrites and activates gene transcription, thereby regulating synaptic function and allowing neuronal circuits to respond dynamically to experience. Evidence indicates that many of the genes that are mutated in autism spectrum disorder are crucial components of the activity-dependent signalling networks that regulate synapse development and plasticity. Dysregulation of activity-dependent signalling pathways in neurons may, therefore, have a key role in the aetiology of autism spectrum disorder.

【 授权许可】

Free