Early progression of a pancreatic metastasis of synovial sarcoma after pancreatectomy

Surgical Case Reports

Case Report

Isamu Makino¹  Shinichi Nakanuma¹  Mitsuyoshi Okazaki¹  Ryousuke Gabata¹  Shintaro Yagi¹  Hiroaki Sugita¹  Kaoru Katano¹  Tomokazu Tokoro¹  Satoshi Takada¹ 

[1] Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kanazawa University, 13-1 Takara-Machi, 920-8641, Kanazawa, Ishikawa, Japan;

关键词: Synovial sarcoma;    Pancreatic metastasis;    Pancreatectomy;   

DOI  :  10.1186/s40792-023-01612-z

 received in 2022-12-29, accepted in 2023-02-15,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundSynovial sarcoma is a malignant tumor that constitutes up to 10% of all soft-tissue sarcomas. The most frequent metastatic sites of synovial sarcoma are the lungs, lymph nodes, and bone, whereas pancreatic metastasis is extremely rare. Here, we report a case of pancreatic metastasis of synovial sarcoma.Case presentationNine years before presentation, a 31-year-old woman underwent extensive resection of the primary tumor after chemotherapy for left upper extremity synovial sarcoma. Six months before presentation, interscapulothoracic amputation was performed for an enlarged mass in the left upper extremity; the patient was treated with pazopanib. Three months before presentation, chest computed tomography showed multiple lung metastases; during subsequent follow-up, abdominal computed tomography revealed a pancreatic metastasis of synovial sarcoma. The doubling time of the pancreatic tumor was 14 days, and it grew rapidly. Furthermore, treatment-resistant pancreatitis symptoms were detected; thus, we performed distal pancreatectomy and administered one course of a 70% dose of trabectedin. However, the patient died of rapid progression of lung metastasis and respiratory failure within 2 months after surgery.ConclusionsPancreatectomy may be carefully performed in cases of isolated pancreatic metastasis. However, the presence of other distant extrapancreatic metastases (e.g., uncontrolled lung metastases) may rule out pancreatectomy treatment.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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