What do we know about pathological mechanism and pattern of lung injury related to SARS-CoV-2 Omicron variant?

Diagnostic Pathology

Comment

Roberto Scendoni¹  Mariano Cingolani¹ 

[1] Department of Law, Institute of Legal Medicine, University of Macerata, Piaggia Dell’Università, 2, 62100, Macerata, Italy;

关键词: SARS-CoV-2 variants;    Omicron;    Immune escape process;    Lung injury;    Pathological pattern;    Diffuse alveolar damage;    Ventilator-induced lung injury;    Comorbidity;    Autopsy;   

DOI  :  10.1186/s13000-023-01306-y

 received in 2022-12-08, accepted in 2023-02-02,  发布年份 2023

来源: Springer

【 摘 要 】

Pulmonary damage in SARS-CoV-2 is characterized pathologically by diffuse alveolar damage (DAD) and thrombosis. In addition, nosocomial bacterial superinfections and ventilator-induced lung injury (VILI) are likely to occur. The SARS-CoV-2 Omicron variant have manifested itself as a more diffusive virus which mainly affects the upper airways, such as the nose and pharynx. The mechanism leading to a lung injury with a complex clinical course for the Omicron SARS-CoV-2 variant remains unclear. A key question is whether the organ damage is due to direct organ targeting of the virus or downstream effects such as an altered immune response. An immune escape process of Omicron variant is being studied, which could lead to prolonged viral shedding and increase hospitalization times in patients with comorbidities, with an increased risk of pulmonary co-infections/superinfections and organ damage. This brief commentary reports the current knowledge on the Omicron variant and provides some useful suggestions to the scientific community.

【 授权许可】

CC BY   
© The Author(s) 2023