期刊论文详细信息
International Journal of Retina and Vitreous
The efficacy of oral pain relief cocktail during pan-retinal photocoagulation for diabetic retinopathy: a randomized clinical trial
Original Article
Abdulrahim Amini1  Mohammadreza Badie2  Fatemeh Sanie-Jahromi2  Mohammadkarim Johari2  Sarah Safniyat2 
[1] Department of Ophthalmology, School of Medicine, Hormozgan University of medical sciences, Bandar Abbas, Iran;Poostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
关键词: Diabetic retinopathy;    Acetaminophen;    Ibuprofen;    Caffeine;    Pregabalin;    Visual analog scale;    Pan-retinal photocoagulation;   
DOI  :  10.1186/s40942-022-00438-5
 received in 2022-11-15, accepted in 2022-12-23,  发布年份 2022
来源: Springer
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【 摘 要 】

Purposeto evaluate the pain-relieving effect of analgesic combinations during pan-retinal photocoagulation (PRP) in patients with non-proliferative diabetic retinopathy (NPDR).MethodsThis study was a randomized, double-blind, placebo-controlled trial. Patients with severe NPDR without previous history of PRP were included in the study. Both eyes of the patients were treated with a pan-retinal photocoagulation procedure. The retina was divided into four quadrants and the treatment plan for patients submitted to PRP was divided into four sessions. Different oral medications were given to patients 1 hour before the procedure. Capsules containing a combination of analgesic drugs (including 325 mg acetaminophen, 200 mg ibuprofen, and 40 mg caffeine, referred to as N), pregabalin capsules (75 mg, referred to as P), a combination of N capsules and P capsules (referred to as NP), and the placebo were used in each session. Each patient scored the pain sensation immediately after the procedure using a visual analog scale (VAS).Result60 eyes of 30 patients were studied. The mean value of VAS in patients receiving the placebo was 3.3 ± 1.822 units, while this scale was 3.067 ± 1.507, 3.5 ± 1.479, and 3.5 ± 1.77 in the N, P, and NP consumed patients, respectively. There was no significant difference in VAS levels and the patient’s vital signs between different sessions (P = 0.512).ConclusionNo evidence of the pain-relieving effect of N, P or NP was found during PRP.Trial registration: IRCT20200915048724N1. Registered 20 October 2020, https://www.irct.ir/trial/51345

【 授权许可】

CC BY   
© The Author(s) 2023

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Fig. 5 698KB Image download
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