The hen and the egg question in atopic dermatitis: allergy or eczema comes first

Asthma Research and Practice

Review

Razvigor Darlenski¹  Anastasiia Allenova² 

[1] Department of Dermatology and Venereology, Acibadem City Clinic Tokuda Hospital Sofia, 51B Nikola Vaptsarov Blvd., 1407, Sofia, Bulgaria;Department of Dermatology and Venereology, Trakia University-Stara Zagora, Stara Zagora, Bulgaria;Laboratory of Immune-Mediated Skin Diseases, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;Medical Research, and Education Center, M.V. Lomonosov Moscow State University, Moscow, Russia;

关键词: Eczema;    Atopy;    Asthma;    Atopic march;    Treatment;   

DOI  :  10.1186/s40733-023-00090-2

 received in 2022-11-30, accepted in 2023-01-30,  发布年份 2023

来源: Springer

【 摘 要 】

Atopic dermatitis (AD) as a chronic inflammatory systemic condition is far more than skin deep. Co-morbidities such as asthma and allergic rhinitis as well as the psychological impact influence seriously the quality of life of the patients. Recent studies have shown that only 10% of atopic patients undergo full manifestation of the atopic march, while 40% demonstrate concomitant food allergy. Exposure to food allergens in the environment causes sensitization and food allergy through the disruption of the skin barrier, as in AD. Food allergy and AD are closely related. While not all AD patients have a food allergy, 20–40% of children with moderate to severe AD will have an IgE-mediated food allergy. It is known that they may coexist but it is unclear if food allergy worsens the course of AD. Experimental, clinical, and epidemiological studies have provided evidence of the primary role of an epidermal barrier defect in the development of sensitization to environmental allergens and that this process occurs in the damaged skin barrier rather than the gastrointestinal or respiratory tract. There is strong evidence for a connection between early AD onset and the development of other allergic diseases later in life.

【 授权许可】

CC BY   
© The Author(s) 2023