Fat infiltration in the thigh muscles is associated with symptomatic spinal stenosis and reduced physical functioning in adults with achondroplasia

Orphanet Journal of Rare Diseases

Research

Mikael Petersson¹  Per Widholm²  Jennifer Linge³  Olof Dahlqvist Leinhard⁴  Grethe Månum⁵  Heidi Beate Eggesbø⁶  Ravi Savarirayan⁷  Harald Weedon-Fekjær⁸  Olga de Vries⁹  Svein O. Fredwall^1,10 

[1] AMRA Medical AB, Linköping, Sweden;AMRA Medical AB, Linköping, Sweden;Center for Medical Image Science and Visualization, University of Linköping, Linköping, Sweden;Department of Radiology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden;AMRA Medical AB, Linköping, Sweden;Department of Health, Medicine and Caring Sciences, University of Linköping, Linköping, Sweden;AMRA Medical AB, Linköping, Sweden;Department of Health, Medicine and Caring Sciences, University of Linköping, Linköping, Sweden;Center for Medical Image Science and Visualization, University of Linköping, Linköping, Sweden;Department of Research, Sunnaas Rehabilitation Hospital, Nesodden, Norway;Division of Radiology and Nuclear Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway;Murdoch Children’s Research Institute and University of Melbourne, Parkville, Australia;Oslo Centre for Biostatistics and Epidemiology, Research Support Service, Oslo University Hospital, Oslo, Norway;Sunnaas Rehabilitation Hospital, TRS National Resource Centre for Rare Disorders, 1450, Nesodden, Norway;Sunnaas Rehabilitation Hospital, TRS National Resource Centre for Rare Disorders, 1450, Nesodden, Norway;Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway;

关键词: Achondroplasia;    Body composition;    Intramuscular fat;    Magnetic resonance imaging;    Muscle fat infiltration;    Rehabilitation;    Spinal stenosis;    6-min walk test;    30-s sit-to-stand test;   

DOI  :  10.1186/s13023-023-02641-5

 received in 2022-03-05, accepted in 2023-02-12,  发布年份 2023

来源: Springer

【 授权许可】

CC BY   
© The Author(s) 2023

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