Reprogramming the tumor microenvironment with biotechnology

Biomaterials Research

Review

Na Kyeong Lee¹  Min Ji Byun¹  Jaesung Lim¹  Minjeong Kim¹  Chi-Pin James Wang¹  Chun Gwon Park²  Dae-Hwan Park³  Wooram Park⁴  Se-Na Kim⁵  Tae-Hyung Kim⁶ 

[1] Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), 16419, Suwon, Gyeonggi, Republic of Korea;Department of Intelligent Precision Healthcare Convergence, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), 16419, Suwon, Gyeonggi, Republic of Korea;Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), 16419, Suwon, Gyeonggi, Republic of Korea;Department of Intelligent Precision Healthcare Convergence, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), 16419, Suwon, Gyeonggi, Republic of Korea;Research and Development Center, MediArk Inc., 28644, Cheongju, Chungbuk, Republic of Korea;Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, 16419, Suwon, Gyeonggi, Republic of Korea;Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), 16419, Suwon, Gyeonggi, Republic of Korea;Department of Engineering Chemistry, Chungbuk National University, 28644, Cheongju, Chungbuk, Republic of Korea;Department of Industrial Cosmetic Science, College of Bio-Health University System, Chungbuk National University, 28644, Cheongju, Chungbuk, Republic of Korea;Department of Synchrotron Radiation Science and Technology, College of Bio-Health University System, Chungbuk National University, 28644, Cheongju, Chungbuk, Republic of Korea;LANG SCIENCE Inc., Chungbuk National University, 28644, Cheongju, Chungbuk, Republic of Korea;Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University (SKKU), 16419, Suwon, Gyeonggi, Republic of Korea;Research and Development Center, MediArk Inc., 28644, Cheongju, Chungbuk, Republic of Korea;School of Integrative Engineering, Chung-Ang University, 84 Heukseok-Ro, Dongjak-Gu, 06974, Seoul, Republic of Korea;

关键词: Tumor microenvironment;    Reprogramming;    Combination treatment;    Nanoparticle;    Biomaterials;   

DOI  :  10.1186/s40824-023-00343-4

 received in 2022-10-28, accepted in 2023-01-22,  发布年份 2023

来源: Springer

【 摘 要 】

The tumor microenvironment (TME) is a unique environment that is developed by the tumor and controlled by tumor-induced interactions with host cells during tumor progression. The TME includes immune cells, which can be classified into two types: tumor- antagonizing and tumor-promoting immune cells. Increasing the tumor treatment responses is associated with the tumor immune microenvironment. Targeting the TME has become a popular topic in research, which includes polarizing macrophage phenotype 2 into macrophage phenotype 1 using Toll-like receptor agonists with cytokines, anti-CD47, and anti-SIPRα. Moreover, inhibiting regulatory T cells through blockades and depletion restricts immunosuppressive cells in the TME. Reprogramming T cell infiltration and T cell exhaustion improves tumor infiltrating lymphocytes, such as CD8+ or CD4+ T cells. Targeting metabolic pathways, including glucose, lipid, and amino acid metabolisms, can suppress tumor growth by restricting the absorption of nutrients and adenosine triphosphate energy into tumor cells. In conclusion, these TME reprogramming strategies exhibit more effective responses using combination treatments, biomaterials, and nanoparticles. This review highlights how biomaterials and immunotherapy can reprogram TME and improve the immune activity.

【 授权许可】

CC BY   
© The Author(s) 2023

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