Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer’s disease

Translational Neurodegeneration

Research

Rocío Ruiz¹  Tomas Deierborg²  Sara Bachiller³  Antonio Boza-Serrano⁴  Antonio Rodríguez-Moreno⁵  Luis Enrique Arroyo-García⁶  André Fisahn⁷  Yuniesky Andrade-Talavera⁸ 

[1] Department of Biochemistry and Molecular Biology, University of Seville, Calle Profesor García González Nº2, 41012, Seville, Spain;Experimental Neuroinflammation Laboratory, Department of Experimental Medical Science, Lund University, BMC B11, 221 84, Lund, Sweden;Experimental Neuroinflammation Laboratory, Department of Experimental Medical Science, Lund University, BMC B11, 221 84, Lund, Sweden;Clinical Unit of Infectious Diseases, Microbiology and Parasitology, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain;Experimental Neuroinflammation Laboratory, Department of Experimental Medical Science, Lund University, BMC B11, 221 84, Lund, Sweden;Department of Biochemistry and Molecular Biology, University of Seville, Calle Profesor García González Nº2, 41012, Seville, Spain;Laboratory of Cellular Neuroscience and Plasticity, Department of Physiology, Anatomy and Cellular Biology, Universidad Pablo de Olavide, Carretera de Utrera Km-1, 41013, Seville, Spain;Neuronal Oscillations Laboratory, Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 17164, Solna, Sweden;Neuronal Oscillations Laboratory, Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 17164, Solna, Sweden;Department of Biosciences and Nutrition, Neo, Karolinska Institutet, 141 83, Huddinge, Sweden;Neuronal Oscillations Laboratory, Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 17164, Solna, Sweden;Laboratory of Cellular Neuroscience and Plasticity, Department of Physiology, Anatomy and Cellular Biology, Universidad Pablo de Olavide, Carretera de Utrera Km-1, 41013, Seville, Spain;

关键词: Galectin-3;    Gamma oscillations;    Neuronal network dynamics;    Fast-spiking interneurons;    Alzheimer’s disease models;    Neuroinflammation;    TD139;    Hippocampus;   

DOI  :  10.1186/s40035-023-00338-0

 received in 2022-10-27, accepted in 2023-01-19,  发布年份 2023

来源: Springer

【 授权许可】

CC BY   
© The Author(s) 2023

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