Ultrasmall and highly biocompatible carbon dots derived from natural plant with amelioration against acute kidney injury

Journal of Nanobiotechnology

Research

Xiaoke Wang¹  Meiling Zhang²  Tong Wu³  Yue Zhang⁴  Yan Zhao⁵  Yafang Zhao⁵  Shuxian Wang⁵  Hui Kong⁵  Long Zhou⁵  Yingxin Yang⁵  Huihua Qu⁶  Jiaxing Liu⁷ 

[1] Encephalopathy Hospital, The First Affiliated Hospital of Henan University of Chinese Medicine, 450000, Zhengzhou, China;Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, 100020, Beijing, China;School of Chinese Materia Medica, Beijing University of Chinese Medicine, 100029, Beijing, China;School of Life Science, Beijing University of Chinese Medicine, 100029, Beijing, China;School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 100029, Beijing, China;School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 100029, Beijing, China;Center of Scientific Experiment, Beijing University of Chinese Medicine, 100029, Beijing, China;Third Affiliated Hospital, Beijing University of Chinese Medicine, 100029, Beijing, China;

关键词: Carbon dots;    Pollen Typhae;    Acute kidney injury;    Biomass;    Rhabdomyolysis;   

DOI  :  10.1186/s12951-023-01795-5

 received in 2022-11-15, accepted in 2023-01-24,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundAcute kidney injury (AKI) refers to a tricky clinical disease, known by its high morbidity and mortality, with no real specific medicine for AKI. The carbonization product from Pollen Typhae (i.e., Pu-huang in China) has been extensively employed in clinic, and it is capable of relieving the renal damage and other diseases in China since acient times.ResultsInspired by the carbonization process of Traditional Chinese Medicine (TCM), a novel species of carbon dots derived from Pollen Typhae (PT-CDs) was separated and then collected using a one-pot pyrolysis method. The as-prepared PT-CDs (4.85 ± 2.06 nm) with negative charge and abundant oxygenated groups exhibited high solubility, and they were stable in water. Moreover, the rhabdomyolysis (RM)-induced AKI rat model was used, and it was first demonstrated that PT-CDs had significant activity in improving the level of BUN and CRE, urine volume and kidney index, and histopathological morphology in RM-induced AKI rats. It is noteworthy that interventions of PT-CDs significantly reduced degree of inflammatory reaction and oxidative stress, which may be correlated with the basial potential mechanism of anti-AKI activities. Furthermore, cytotoxicity assay and biosafety evaluation exhibited high biocompatibility of PT-CDs.ConclusionThis study offers a novel relieving strategy for AKI based on PT-CDs and suggests its potential to be a related candidate for clinical applications.Graphical Abstract

【 授权许可】

CC BY   
© The Author(s) 2023

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