A revised compartmental model for biokinetics and dosimetry of 2-[18F]FDG

EJNMMI Physics

Original Research

Alexandra Kamp¹  Augusto Giussani¹  Dietmar Noβke²  Martin Andersson³  Sören Mattsson⁴  Sigrid Leide-Svegborn⁴ 

[1] Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection (BfS), Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany;Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection (BfS), Neuherberg, Germany;Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;Medical Radiation Physics Malmö, Department of Translational Medicine, Lund University, Malmö, Sweden;Medical Radiation Physics Malmö, Department of Translational Medicine, Lund University, Malmö, Sweden;

关键词: Nuclear medicine;    Fluorodeoxyglucose;    Biodistribution;    Absorbed organ dose;    Effective dose;   

DOI  :  10.1186/s40658-023-00528-9

 received in 2022-05-19, accepted in 2023-01-26,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe aim was to review available biokinetic data, collect own experimental data, and propose an updated compartmental model for 2-[18F]FDG in the frame of the revision of the ICRP report on dose coefficients for radiopharmaceuticals used in diagnostic nuclear medicine.MethodsThe compartmental model was developed based on published biokinetic data for 2-[18F]FDG. Additional data on urinary excretion in 23 patients (11 males, 12 females) undergoing whole-body PET/CT examinations were obtained within this study. The unknown biokinetic model parameters were derived using the software SAAM II and verified with a modified version of IDAC-Iodide. Dose coefficients for reference adults were calculated with the programme IDAC-Dose 2.1. A dynamic bladder model was employed for urinary bladder dosimetry.ResultsThe proposed model consists of following compartments: blood, heart wall, brain, liver, lungs, pancreas, spleen, kidneys, urinary bladder content and a generic pool compartment “Other”. The latter was introduced to account for 2-[18F]FDG in body organ and tissues besides the explicitly modelled ones. The model predictions showed a good agreement with experimental data. Urinary bladder wall received the highest absorbed dose coefficient of 7.5E−02 mGy/MBq under the assumption of initial urine volume of 100 ml, first voiding at 45 min p.i. and 3.75 h voiding intervals thereafter. The effective dose coefficient calculated according to the current dosimetry framework of ICRP amounted to 1.7E−02 mSv/MBq, compared to 1.9E−02 mSv/MBq in ICRP Publication 128.ConclusionA compartmental model for 2-[18F]FDG was proposed and will be used to replace the descriptive biokinetic model of ICRP Publication 128. The revised model and the provided dose coefficients are expected to improve reference dosimetry for patients administered with 2-[18F]FDG.

【 授权许可】

CC BY   
© The Author(s) 2023

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