Biological target volume based on fluorine-18-fluorode-oxyglucose positron emission tomography/computed tomography imaging: a spurious proposition?

Radiation Oncology

Research

Li Li¹  Zhaodong Fei¹  Ting Xu¹  Yiying Xu¹  Xiufang Qiu¹  Jianming Ding¹  Jiawei Chen¹  Chaoxiong Huang¹  Ye Feng¹  Huiling Hong¹  Chuanben Chen¹ 

[1] Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma Road, 350014, Fuzhou, Fujian, People’s Republic of China;

关键词: Nasopharyngeal carcinoma;    F-FDG-PET/CT;    Biological target volume;    Local recurrence;    Standardized uptake value;   

DOI  :  10.1186/s13014-023-02225-4

 received in 2022-11-25, accepted in 2023-02-12,  发布年份 2023

来源: Springer

【 摘 要 】

PurposeTo assess whether the high metabolic region of fluorine-18-fluorode-oxyglucose (18F-FDG) in the primary lesion is the crux for recurrence in patients with nasopharyngeal carcinoma (NPC), to assess the feasibility and rationale for use of biological target volume (BTV) based on 18F-FDG positron emission tomography/computed tomography (18F-FDG-PET/CT).MethodsThe retrospective study included 33 patients with NPC who underwent 18F-FDG-PET/CT at the time of initial diagnosis as well as the time of diagnosis of local recurrence. Paired 18F-FDG-PET/CT images for primary and recurrent lesion were matched by deformation coregistration method to determine the cross-failure rate between two lesions.ResultsThe median volume of the Vpri (primary tumor volume using the SUV thresholds of 2.5), the Vhigh (the volume of high FDG uptake using the SUV50%max isocontour), and the Vrecur (the recurrent tumor volume using the SUV thresholds of 2.5) were 22.85, 5.57, and 9.98 cm3, respectively. The cross-failure rate of Vrecur∩high showed that 82.82% (27/33) of local recurrent lesions had < 50% overlap volume with the region of high FDG uptake. The cross-failure rate of Vrecur∩pri showed that 96.97% (32/33) of local recurrent lesions had > 20% overlap volume with the primary tumor lesions and the median cross rate was up to 71.74%.Conclusion18F-FDG-PET/CT may be a powerful tool for automatic target volume delineation, but it may not be the optimal imaging modality for dose escalation radiotherapy based on applicable isocontour. The combination of other functional imaging could delineate the BTV more accurately.

【 授权许可】

CC BY   
© The Author(s) 2023

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