Exploration of the underlying comorbidity mechanism in psoriasis and periodontitis: a bioinformatics analysis

Hereditas

Research

Zixuan Xing¹  Ruimin Bai¹  Yan Zheng¹  Ke He¹  Hao Lei¹  Wenqian Du¹  Yan Wang¹  Wen Zhang¹  Ziyang Wang²  Xin Chen³ 

[1] Department of Dermatology, the First Affiliated Hospital of Xi’an Jiaotong University, 710061, Xi’an, China;Department of Medicine, Xi’an Jiaotong University, 710061, Xi’an, China;State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, 710032, Xi’an, China;

关键词: Psoriasis;    Periodontitis;    Differentially expressed genes (DEGs);    Comorbidity;    Bioinformatics;   

DOI  :  10.1186/s41065-023-00266-z

 received in 2022-06-14, accepted in 2023-01-12,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundIncreasing evidence indicates that psoriasis (PSO) and periodontitis (PD) are likely to occur together, however, the underlying mechanism remains unclear.Materials and methodsThe expression profiles of PSO (lesion vs non-lesion, GSE30999, GSE14905) and PD (affected vs unaffected gingival tissue, GSE16134, GSE10334) were downloaded from the GEO database. First, we investigated the common differentially expressed genes (DEGs) of PSO and PD. Then, GO and KEGG enrichment analysis, protein interaction network (PPI) construction, and hub gene identification analysis were carried out. Finally, GO and KEGG enrichment analysis, miRNA interaction analysis, and transcription factors (TFs) interaction analysis for hub genes were performed.ResultsEighteen DEGs were identified for further analysis, including 15 up-regulated genes and 3 down-regulated genes. 9 hub genes were then identified via Cytohubba, including IL1B, CXCL1, CXCL8, MMP12, CCL18, SELL, CXCL13, FCGR3B, and SELE. Their functions are mainly enriched in two aspects: neutrophil chemotaxis and migration, chemokine activation and interaction. The enriched signaling pathways includes three categories: host defense, inflammation-related signaling pathways, and disease-related pathways. 9 common miRNAs based on experimental evidence and 10 common TFs were further identified in both PSO and PD.ConclusionOur study revealed possible comorbidity mechanisms in PSO and PD from the perspective of bioinformatics tentatively. The data can present new insight for joint prevention and treatment of in PSO and PD, as well as provide data support for further prospective studies.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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