Identification and validation of novel lung adenocarcinoma subtypes and construction of prognostic models: based on cuprotosis-related genes

BMC Pulmonary Medicine

Research

Xiaohua Hong¹  Anqiao Wang²  Guangyao Wang³  Li Wang³  Fang Fang³  Guanglan Xu³ 

[1] Guangxi University of Chinese Medicine, 530000, NanNing, China;Longgang District People’s Hospital of Shenzhen, 518038, Shenzhen, China;The First Affiliated Hospital of Guangxi University of Chinese Medicine, 530000, Nanning, China;

关键词: Cuprotosis;    Lung adenocarcinoma;    Prognosis;    Risk profile;    Immune infiltration;   

DOI  :  10.1186/s12890-023-02350-6

 received in 2022-05-08, accepted in 2023-02-01,  发布年份 2023

来源: Springer

【 摘 要 】

Cuprotosis is a novel and unique form of cell death that is of great value in a variety of cancers. However, the prognostic role of cuprotosis-related genes (CRGs) in lung cancer remains undetermined. We compared the expression profile of CRGs in lung adenocarcinoma (LUAD) patients, revealing the genetic alterations and inter-gene correlations of CRGs. Based on 13 CRGs, LUAD patients could be well differentiated into two molecular subgroups, and the differentially expressed genes (DEGs) in these molecular subtypes were identified. Furthermore, 10 cuprotosis pattern-related DEGs with a significant prognostic value were obtained for constructing a prognostic model. Through validation in an external validation set, the prognostic model based on the CRGs-risk score showed the robust and effective predictive ability and served as an independent prognostic indicator for LUAD patients. Therefore, combining the CRGs-risk score with multiple factors such as clinicopathological characteristics, a quantitative nomogram was developed to predict the survival and prognosis of LUAD patients, improving the clinical application value of the CRGs-risk score. In the low CRGs-risk score group, the related immune cell infiltration was increased and the immune function was activated in LUAD patients. This study may add to the knowledge of CRGs in LUAD, partly contribute to evaluating the prognosis of LUAD patients, and provide direction for the development of targeted therapy and immunotherapy.

【 授权许可】

CC BY   
© The Author(s) 2023

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