High levels of unbound bilirubin are associated with acute bilirubin encephalopathy in post-exchange transfusion neonates

Italian Journal of Pediatrics

Research

Aizhen Zhang¹  Rui Guo¹  Yufang Zhu¹  Yiyi Ding¹  Shuo Wang² 

[1] Department of Pediatrics, The First People’s Hospital of Changde, 415003, Changde, China;Jishou University School of Medicine, 416007, Jishou, China;

关键词: Neonatal;    Acute bilirubin encephalopathy;    Exchange transfusion;    Unbound bilirubin;   

DOI  :  10.1186/s13052-021-01143-z

 received in 2021-05-12, accepted in 2021-08-30,  发布年份 2021

来源: Springer

【 摘 要 】

BackgroundAlthough it is known that unbound bilirubin can enter the brain, there is little evidence of its association with the development of acute bilirubin encephalopathy. Here, we investigated this potential relationship in neonates who had undergone exchange transfusion.MethodsData from 46 newborns who underwent exchange transfusion between 2016 and 1-1 to 2018-12-31 at the First People’s Hospital of Changde City in China were analyzed. The unbound bilirubin level was taken as the independent variable and the development of the acute bilirubin encephalopathy as the dependent variable. The covariates were age, birth weight, sex, red blood cell count, blood glucose, hemolytic disease, and whether the infant had received phototherapy.ResultsThe mean age and gestational age of the neonates were 146.5 ± 86.9 h and 38.6 ± 1.3 weeks [38.7(34.6–41.1) weeks] old, respectively; 52.17% were male. Binary logistic regression analysis after adjustment for covariates showed a positive association between the levels of unbound bilirubin and the development of acute bilirubin encephalopathy (odds ratio = 1.41, 95% confidence intervals 1.05–1.91, P = < 0.05).ConclusionThere is a significant association between unbound bilirubin levels and the development of acute bilirubin encephalopathy in neonates. Further investigations are required to explore the mechanisms.

【 授权许可】

CC BY   
© The Author(s) 2021

【 图 表 】

Fig. 6

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