The role and regulation of Maf proteins in cancer

Biomarker Research

Review

Ting Liu¹  Ying Fu²  Yalan Deng²  Liqing Lu³  Huajun Zhang⁴  Yongheng Chen⁵ 

[1] Department of Gastroenterology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;Department of Thoracic Surgery, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;Department of Ultrasonic Imaging, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;

关键词: Maf proteins;    Proliferation;    Metastasis;    Biomarkers;    Therapeutic targets;   

DOI  :  10.1186/s40364-023-00457-w

 received in 2022-08-25, accepted in 2023-01-22,  发布年份 2023

来源: Springer

【 摘 要 】

The Maf proteins (Mafs) belong to basic leucine zipper transcription factors and are members of the activator protein-1 (AP-1) superfamily. There are two subgroups of Mafs: large Mafs and small Mafs, which are involved in a wide range of biological processes, such as the cell cycle, proliferation, oxidative stress, and inflammation. Therefore, dysregulation of Mafs can affect cell fate and is closely associated with diverse diseases. Accumulating evidence has established both large and small Mafs as mediators of tumor development. In this review, we first briefly describe the structure and physiological functions of Mafs. Then we summarize the upstream regulatory mechanisms that control the expression and activity of Mafs. Furthermore, we discuss recent studies on the critical role of Mafs in cancer progression, including cancer proliferation, apoptosis, metastasis, tumor/stroma interaction and angiogenesis. We also review the clinical implications of Mafs, namely their potential possibilities and limitations as biomarkers and therapeutic targets in cancer.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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