Effect of oral gargle containing Lespedeza cuneata extract on periodontal health improvement and disease prevention: a randomized, controlled clinical trial

BMC Oral Health

Research

Seoul-Hee Nam¹  Yu-Rin Kim² 

[1] Department of Dental Hygiene, College of Health Sciences, Kangwon National University, 346 Hwangjo-Gil, Dogye-Up, 25945, Samcheok-Si, Gangwon-Do, Republic of Korea;Department of Dental Hygiene, Silla University, 46958, 140 Baegyang-daero 700beon-gil, Sasang-gu, Busan, Republic of Korea;

关键词: Periodontal health;    Lespedeza cuneata;    Natural extract;    Clinical study;   

DOI  :  10.1186/s12903-023-02816-3

 received in 2022-11-17, accepted in 2023-02-14,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThis study aimed to evaluate the antiplaque and antibacterial effects of a mouthwash containing Lespedeza cuneata (LC) extract through clinical periodontal disease (PD) indicators and changes in PD-causing bacteria.MethodsA total of 63 subjects participated in this double-blind clinical trial. Subjects were divided into two groups: 32 participants gargled with LC extract, and 31 used saline. Scaling was performed 1 week before the experiment to secure the homogeneity of the subjects’ oral conditions. After gargling with 15 ml of each solution for 1 min, participants spit out the solution to remove any residual mouthwash solution. Then, PD-related bacteria were measured via the O’Leary index, plaque index (PI), and gingival index (GI). The clinical data were collected three times: before gargling, immediately after gargling, and 5 d after gargling.ResultsAfter 5 d, the O’Leary index, PI, and GI scores were significantly reduced in the LC extract gargle group (p < 0.05). PD-inducing Gram-positive and -negative bacteria were also reduced, confirming the LC extract’s effect on periodontal health improvement and disease prevention.ConclusionMouthwash containing LC extract, a new alternative natural substance that is safe and effective, may be used to treat PD because of its ability to inhibit and prevent PD.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 4