Delineation of recurrent glioblastoma by whole brain spectroscopic magnetic resonance imaging

Radiation Oncology

Research

Michael E. Ivan¹  Macarena I. de la Fuente²  Maria del Pilar Guillermo Prieto Eibl²  William Jin³  Eric A. Mellon³  Matthew C. Abramowitz³  Tejan Diwanji³  Jonathan B. Bell³  Gregory A. Azzam³  Mohammed Z. Goryawala⁴ 

[1] Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA;Department of Neurology and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA;Department of Radiation Oncology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, 1475 NW 12th Ave, 33136, Miami, FL, USA;Department of Radiology, Miller School of Medicine, University of Miami, Miami, FL, USA;

关键词: Recurrent glioblastoma;    Spectroscopic MRI;    Re-irradiation;    Glioblastoma;   

DOI  :  10.1186/s13014-023-02219-2

 received in 2022-10-28, accepted in 2023-01-31,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundGlioblastoma (GBM) cellularity correlates with whole brain spectroscopic MRI (sMRI) generated relative choline to N-Acetyl-Aspartate ratio (rChoNAA) mapping. In recurrent GBM (rGBM), tumor volume (TV) delineation is challenging and rChoNAA maps may assist with re-RT targeting.MethodsFourteen rGBM patients underwent sMRI in a prospective study. Whole brain sMRI was performed to generate rChoNAA maps. TVs were delineated by the union of rChoNAA ratio over 2 (rChoNAA > 2) on sMRI and T1PC. rChoNAA > 2 volumes were compared with multiparametric MRI sequences including T1PC, T2/FLAIR, diffusion-restriction on apparent diffusion coefficient (ADC) maps, and perfusion relative cerebral blood volume (rCBV).ResultsrChoNAA > 2 (mean 27.6 cc, range 6.6–79.1 cc) was different from other imaging modalities (P ≤ 0.05). Mean T1PC volumes were 10.7 cc (range 1.2–31.4 cc). The mean non-overlapping volume of rChoNAA > 2 and T1PC was 29.2 cm3. rChoNAA > 2 was 287% larger (range 23% smaller–873% larger) than T1PC. T2/FLAIR volumes (mean 111.7 cc, range 19.0–232.7 cc) were much larger than other modalities. rCBV volumes (mean 6.2 cc, range 0.2–19.1 cc) and ADC volumes were tiny (mean 0.8 cc, range 0–3.7 cc). Eight in-field failures were observed. Three patients failed outside T1PC but within rChoNAA > 2. No grade 3 toxicities attributable to re-RT were observed. Median progression-free and overall survival for re-RT patients were 6.5 and 7.1 months, respectively.ConclusionsTreatment of rGBM may be optimized by sMRI, and failure patterns suggest benefit for dose-escalation within sMRI-delineated volumes. Dose-escalation and radiologic-pathologic studies are underway to confirm the utility of sMRI in rGBM.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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