Circadian Timing, Information processing and Metabolism (TIME) study: protocol of a longitudinal study of sleep duration, circadian alignment and cardiometabolic health among overweight adults

BMC Endocrine Disorders

Study Protocol

Bradley M. Appelhans¹  Tom Greene²  Chelsea M. Allen²  Helen J. Burgess³  Kelly Glazer Baron⁴  Lauretta Quinn⁵ 

[1] Department of Family and Preventive Medicine, Rush University Medical Center, Chicago, IL, US;Department of Population Health Sciences, University of Utah, Salt Lake City, UT, US;Department of Psychiatry, University of Michigan, Ann Arbor, MI, US;Division of Public Health, Department of Family and Preventive Medicine, University of Utah, 375 Chipeta Way, Suite A, 84108, Salt Lake City, UT, US;School of Nursing, University of Illinois at Chicago, Chicago, IL, US;

关键词: Obesity;    Metabolism;    Circadian;    Sleep;    Diet;   

DOI  :  10.1186/s12902-023-01272-y

 received in 2022-11-11, accepted in 2023-01-13,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundBoth short sleep duration and circadian rhythm misalignment are risk factors for metabolic dysfunction, but the underlying mechanisms are unknown. The goal of this study is to examine how sleep duration and circadian alignment predict changes in cardiometabolic risk factors over a 12-month period, and test cognitive function and hedonic eating tendencies as potential mechanisms.MethodsWe will recruit a sample of 120 working aged adults with BMI 25–35 kg/m2 (overweight to class I obesity). The protocol includes 5 visits over a 12-month period. Study visits include wrist actigraphy to measure sleep behaviors, 24-h diet recalls, dim light melatonin collection, a computerized neurobehavioral assessment, eating in the absence of hunger task, and frequently sampled IV glucose tolerance test.DiscussionThe results of the TIME study will advance the understanding of how both short sleep duration and circadian misalignment contribute to behavioral aspects of obesity and metabolic dysfunction.Trial registrationClinicalTrials.Gov, NCT04759755, registered retrospectively February 13, 2021.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 5