Adverse drugs reactions to paracetamol and ibuprofen in children: a 5-year report from a pediatric poison control center in Italy

Italian Journal of Pediatrics

Research

Mara Pisani¹  Alberto Villani¹  Corrado Cecchetti²  Claudia Memoli³  Marco Marano⁴  Marco Roversi⁵  Flavia Severini⁵  Antonio Musolino⁵ 

[1] Department of Emergency, Acceptance and General Pediatrics, Bambino Gesù Children’s Hospital, Rome, Italy;Pediatric Intensive Care Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy;Pediatric Poison Control Centre, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy;Pediatric Poison Control Centre, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy;Pediatric Intensive Care Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy;Residency School of Pediatrics, University of Rome Tor Vergata, Rome, Italy;

关键词: Pediatric poisoning;    Antipyretics;    Analgesics;    Non-steroidal anti-inflammatory drugs;    Paracetamol;    Acetaminophen;    Ibuprofen;   

DOI  :  10.1186/s13052-023-01427-6

 received in 2022-12-29, accepted in 2023-02-08,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThis study aimed to analyze all the patients who contacted the hospital’s pediatric poison control center (PPCC) for exposure to ibuprofen and acetaminophen, in order to assess the incidence of any adverse reactions.MethodsWe retrospectively reported the clinical data of children who accessed the PPCC of the Bambino Gesù Children’s Hospital, IRCCS, Rome, from January 1, 2018 to September 30, 2022 due to wrong, accidental or intentional intake of inappropriate doses of acetaminophen and/or ibuprofen. In addition, we compared patients according to the intake of one of the two drugs and reported the trimestral distribution of cases during the study period.ResultsA total of 351 patients accessed the PPCC during the study period. The median age was 3.0 years. Most patients were females (57.8%). The most common reason for inappropriate oral intake of paracetamol or ibuprofen was a wrong use or an accidental intake (78.6%), with a fifth of patients taking the drug with suicidal intent (21.1%). According to the PPCC evaluation, most patients were not intoxicated (70.4%). Hospitalization was required for 30.5% of patients. Adverse reactions were reported in 10.5% of cases, with a similar incidence in patients who took paracetamol or ibuprofen. Nausea and vomiting were the most commonly reported adverse reactions. A higher frequency of moderate intoxication was found in patients who took paracetamol compared to ibuprofen (p = 0.001). The likelihood of intoxication was also higher in the paracetamol cohort. A spike of cases was registered at the end of 2021.ConclusionsWe analyze exposures to the two most commonly used pediatric molecules, paracetamol and ibuprofen, to assess the frequency of adverse reactions. We demonstrated that these relatively “safe” drugs may be associated with intoxications and adverse reactions when inappropriately administered.

【 授权许可】

CC BY   
© The Author(s) 2023