Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer

World Journal of Surgical Oncology

Research

Shyh-Ming Kuo¹  Chi-Chang Chang²  Chia-Chi Chen³  Fu-Mei Chung⁴  Teng-Hung Yu⁵  Cheng-Ching Wu⁵  Wei-Chin Hung⁵  Chia-Chang Hsu⁶  Yau-Jiunn Lee⁷  Ching-Ting Wei⁸ 

[1] Department of Biomedical Engineering, I-Shou University, 82445, Kaohsiung, Taiwan;Department of Obstetrics & Gynecology, E-Da Hospital/E-Da Dachang Hospital, 82445, Kaohsiung, Taiwan;School of Medicine for International Students, College of Medicine, I-Shou University, 82445, Kaohsiung, Taiwan;Department of Pathology, E-Da Hospital, 82445, Kaohsiung, Taiwan;College of Medicine, I-Shou University, 82445, Kaohsiung, Taiwan;Division of Cardiology, Department of Internal Medicine, E-Da Hospital, 82445, Kaohsiung, Taiwan;Division of Cardiology, Department of Internal Medicine, E-Da Hospital, 82445, Kaohsiung, Taiwan;School of Medicine, College of Medicine, I-Shou University, 82445, Kaohsiung, Taiwan;Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, 82445, Kaohsiung, Taiwan;Health Examination Center, E-Da Dachang Hospital, 80794, Kaohsiung, Taiwan;The School of Chinese Medicine for Post Baccalaureate, College of Medicine, I-Shou University, 82445, Kaohsiung, Taiwan;Lee’s Endocrinologic Clinic, 90000, Pingtung, Taiwan;The School of Chinese Medicine for Post Baccalaureate, College of Medicine, I-Shou University, 82445, Kaohsiung, Taiwan;Division of General Surgery, Department of Surgery, E-Da Hospital, No. 1, Yi-Da Rd., Jiau-Shu Village, Yan-Chao Township, 82445, Kaohsiung, Taiwan;Department of Biomedical Engineering, I-Shou University, 82445, Kaohsiung, Taiwan;Department of Electrical Engineering, I-Shou University, 82445, Kaohsiung, Taiwan;

关键词: Liver-type fatty acid-binding protein;    Concentrations;    Expression;    Breast cancer;   

DOI  :  10.1186/s12957-023-02944-8

 received in 2022-07-20, accepted in 2023-02-11,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundLiver-type fatty acid-binding protein (L-FABP) is widely expressed in hepatocytes and plays a role in lipid metabolism. It has been demonstrated to be overexpressed in different types of cancer; however, few studies have investigated the association between L-FABP and breast cancer. The aim of this study was to assess the association between plasma concentrations of L-FABP in breast cancer patients and the expression of L-FABP in breast cancer tissue.MethodA total of 196 patients with breast cancer and 57 age-matched control subjects were studied. Plasma L-FABP concentrations were measured using ELISA in both groups. The expression of L-FABP in breast cancer tissue was examined using immunohistochemistry.ResultThe patients had higher plasma L-FABP levels than the controls (7.6 ng/mL (interquartile range 5.2–12.1) vs. 6.3 ng/mL (interquartile range 5.3–8.5), p = 0.008). Multiple logistic regression analysis showed an independent association between L-FABP and breast cancer, even after adjusting for known biomarkers. Moreover, the rates of pathologic stage T2+T3+T4, clinical stage III, positive HER-2 receptor status, and negative estrogen receptor status were significantly higher in the patients with an L-FABP level greater than the median. Furthermore, the L-FABP level gradually increased with the increasing stage. In addition, L-FABP was detected in the cytoplasm, nuclear, or both cytoplasm and nuclear of all breast cancer tissue examined, not in the normal tissue.ConclusionsPlasma L-FABP levels were significantly higher in the patients with breast cancer than in the controls. In addition, L-FABP was expressed in breast cancer tissue, which suggests that L-FABP may be involved in the pathogenesis of breast cancer.

【 授权许可】

CC BY   
© The Author(s) 2023

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