Circadian disruption and sleep disorders in neurodegeneration

Translational Neurodegeneration

Review

Sheng Zhuang¹  Wei-ye Xie¹  Yun Shen¹  Si-yi Gong²  Cheng-jie Mao³  Qian-kun Lv³  Chun-feng Liu³  Jun-yi Liu⁴ 

[1] Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, 215004, Suzhou, China;Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, 215004, Suzhou, China;Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong SAR, China;Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, 215004, Suzhou, China;Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, 215123, Suzhou, China;Department of Neurology, Dushu Lake Hospital Affiliated to Soochow University, 215125, Suzhou, China;

关键词: Circadian disruption;    Sleep disorder;    Parkinson’s disease;    Alzheimer’s disease;   

DOI  :  10.1186/s40035-023-00340-6

 received in 2022-10-30, accepted in 2023-02-03,  发布年份 2023

来源: Springer

【 摘 要 】

Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional relationship between disruptions of circadian rhythms and sleep cycles and neurodegenerative diseases. Circadian disruption and sleep disorders aggravate neurodegeneration and neurodegenerative diseases can in turn disrupt circadian rhythms and sleep. Importantly, circadian disruption and various sleep disorders can increase the risk of neurodegenerative diseases. Thus, harnessing the circadian biology findings from preclinical and translational research in neurodegenerative diseases is of importance for reducing risk of neurodegeneration and improving symptoms and quality of life of individuals with neurodegenerative disorders via approaches that normalize circadian in the context of precision medicine. In this review, we discuss the implications of circadian disruption and sleep disorders in neurodegenerative diseases by summarizing evidence from both human and animal studies, focusing on the bidirectional links of sleep and circadian rhythms with prevalent forms of neurodegeneration. These findings provide valuable insights into the pathogenesis of neurodegenerative diseases and suggest a promising role of circadian-based interventions.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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