Prospective use of amniotic mesenchymal stem cell metabolite products for tissue regeneration

Journal of Biological Engineering

Review

Dewi Melani Hariyadi¹  Andang Miatmoko²  Ram Kumar Sahu³  Syarifah Sutra Dewangga⁴  Kevin Ksatria Handoko⁴  Devy Maulidya Cahyani⁵  Berlian Sarasitha Hariawan⁵ 

[1] Department of Pharmaceutical Science, Faculty of Pharmacy, Universitas Airlangga, Nanizar Zaman Joenoes Building, Campus C UNAIR Mulyorejo, 60115, Mulyorejo, Surabaya, East Java, Indonesia;Department of Pharmaceutical Science, Faculty of Pharmacy, Universitas Airlangga, Nanizar Zaman Joenoes Building, Campus C UNAIR Mulyorejo, 60115, Mulyorejo, Surabaya, East Java, Indonesia;Stem Cell Research and Development Center, Universitas Airlangga, 2nd Floor Institute of Tropical Disease Building, Campus C UNAIR Mulyorejo, 60115, Surabaya, Indonesia;Department of Pharmaceutical Sciences, Hemvati Nandan Bahuguna Garhwal University (A Central University), Chauras Campus, 249161, Tehri Garhwal, Uttarakhand, India;Faculty of Pharmacy, Study Program of Pharmacy, Universitas Airlangga, Campus C UNAIR Mulyorejo, 60115, Surabaya, Indonesia;Master Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Campus C UNAIR Mulyorejo, 60115, Surabaya, Indonesia;

关键词: Quality-adjusted life-year;    Amniotic mesenchymal stem cell metabolite products;    Growth factors;    Tissue injury;    Stem cells;    Molecular therapy;   

DOI  :  10.1186/s13036-023-00331-1

 received in 2022-09-09, accepted in 2023-02-06,  发布年份 2023

来源: Springer

【 摘 要 】

Chronic disease can cause tissue and organ damage constituting the largest obstacle to therapy which, in turn, reduces patients’ quality-adjusted life-year. Degenerative diseases such as osteoporosis, Alzheimer’s disease, Parkinson’s disease, and infectious conditions such as hepatitis, cause physical injury to organs. Moreover, damage resulting from chronic conditions such as diabetes can also culminate in the loss of organ function. In these cases, organ transplantation constitutes the therapy of choice, despite the associated problems of immunological rejection, potential disease transmission, and high morbidity rates. Tissue regeneration has the potential to heal or replace tissues and organs damaged by age, disease, or trauma, as well as to treat disabilities. Stem cell use represents an unprecedented strategy for these therapies. However, product availability and mass production remain challenges. A novel therapeutic alternative involving amniotic mesenchymal stem cell metabolite products (AMSC-MP) has been developed using metabolites from stem cells which contain cytokines and growth factors. Its potential role in regenerative therapy has recently been explored, enabling broad pharmacological applications including various gastrointestinal, lung, bladder and renal conditions, as well as the treatment of bone wounds, regeneration and skin aging due to its low immunogenicity and anti-inflammatory effects. The various kinds of growth factors present in AMSC-MP, namely bFGF, VEGF, TGF-β, EGF and KGF, have their respective functions and activities. Each growth factor is formed by different proteins resulting in molecules with various physicochemical properties and levels of stability. This knowledge will assist in the manufacture and application of AMSC-MP as a therapeutic agent.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 1