Surgical resection of a retroperitoneal liposarcoma producing insulin-like growth factor II: a case report

Surgical Case Reports

Case Report

Izumi Fukuda¹  Mototsugu Nagao¹  Koji Ohta²  Naruyuki Kobayashi²  Noriyuki Nishiwaki²  Fumiaki Takatsu²  Ryoji Ochiai²  Tomokazu Kakishita²  Yoshihiro Mikuriya²  Takaya Kobatake²  Shinji Hato²  Norihiro Teramoto³ 

[1]Department of Endocrinology, Metabolism and Nephrology, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, 113-8603, Tokyo, Japan

[2]Department of Gastroenterological Surgery, National Hospital Organization, Shikoku Cancer Center, 160, Ko, Minamiumemoto-machi, 791-0280, Matsuyama-shi, Ehime-Ken, Japan

[3]Department of Pathology, National Hospital Organization, Shikoku Cancer Center, 160, Ko, Minamiumemoto-machi, 791-0280, Matsuyama-shi, Ehime-Ken, Japan

关键词: Liposarcoma;    Insulin-like growth factor;    Hypoglycemia;   

DOI  :  10.1186/s40792-023-01589-9

 received in 2022-12-22, accepted in 2023-01-11,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundTumor-produced high molecular weight insulin-like growth factor-II (big insulin-like growth factor-II) is considered to cause non-islet cell tumor hypoglycemia. This paper presents a case of surgically resected retroperitoneal liposarcoma that produced big insulin-like growth factor-II.Case presentationHere, we report the case of a 62-year-old woman who presented with an abdominal mass and hypoglycemia. Non-islet cell tumor hypoglycemia due to retroperitoneal liposarcoma was suspected. After complete resection of the tumor, the patient’s hypoglycemia improved and big insulin-like growth factor-II disappeared in the molecular weight analysis of serum insulin-like growth factor-II by western blotting. The patient had no tumor recurrence or reappearance of hypoglycemia 16 months after the operation without any adjuvant therapy.ConclusionsAlthough insulin-like growth factor-II-producing tumors are generally large and difficult to operate on, surgical resection is currently the most effective and only treatment; thus, it is essential to attempt resection aggressively.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 3

Fig. 1