Deep learning model integrating positron emission tomography and clinical data for prognosis prediction in non-small cell lung cancer patients

BMC Bioinformatics

Research

In-Jae Oh¹  Seungwon Oh²  Min-Soo Kim²  Sae-Ryung Kang³ 

[1] Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam, Republic of Korea;Department of Mathematics and Statistics, Chonnam National University, Gwangju, Republic of Korea;Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam, Republic of Korea;

关键词: Deep learning;    Survival prediction;    Lung cancer;    Multimodal learning;    FDG PET;   

DOI  :  10.1186/s12859-023-05160-z

 received in 2023-01-11, accepted in 2023-01-25,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundLung cancer is the leading cause of cancer-related deaths worldwide. The majority of lung cancers are non-small cell lung cancer (NSCLC), accounting for approximately 85% of all lung cancer types. The Cox proportional hazards model (CPH), which is the standard method for survival analysis, has several limitations. The purpose of our study was to improve survival prediction in patients with NSCLC by incorporating prognostic information from F-18 fluorodeoxyglucose positron emission tomography (FDG PET) images into a traditional survival prediction model using clinical data.ResultsThe multimodal deep learning model showed the best performance, with a C-index and mean absolute error of 0.756 and 399 days under a five-fold cross-validation, respectively, followed by ResNet3D for PET (0.749 and 405 days) and CPH for clinical data (0.747 and 583 days).ConclusionThe proposed deep learning-based integrative model combining the two modalities improved the survival prediction in patients with NSCLC.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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