Serum γ-glutamyltransferase level and incidence risk of metabolic syndrome in community dwelling adults: longitudinal findings over 12 years

Diabetology & Metabolic Syndrome

Research

Yong-Jae Lee¹  In-Ho Seo¹  Jiwon Kwak¹ 

[1]Department of Family Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, 211 Eonju-ro, Gangnam-Gu, 06273, Seoul, Republic of Korea

关键词: Metabolic syndrome;    γ-glutamyltransferase;    Oxidative stress;    Epidemiology;   

DOI  :  10.1186/s13098-023-01000-5

 received in 2022-11-30, accepted in 2023-02-17,  发布年份 2023

来源: Springer

【 摘 要 】

PurposeAlthough a recent meta-analysis demonstrated a positive association between serum γ-glutamyltransferase (GGT) and metabolic syndrome (MetS), sex differences in the relationship between GGT levels and MetS risk were not fully considered. We prospectively examined the relationship between serum GGT levels and incidence risk of MetS.MethodsData were collected from the Korean Genome and Epidemiology Study (KoGES) enrolled in 2001–2002. Among 10,030 total participants, 5960 adults (3130 men and 2830 women) aged 40–69 without MetS were included and divided according to sex-specific quartiles of baseline serum GGT levels and followed up biennially until 2014. The hazard ratios (HRs) with 95% confidence intervals (CIs) for incident MetS were prospectively analyzed using multiple Cox proportional hazards regression analysis models.ResultsAmong 5960 participants, 1215 males (38.8%) and 1263 females (44.6%) developed MetS during 12-year follow up. Higher quartiles of GGT showed significantly higher cumulative incidence of MetS in both sexes (log-rank test P < 0.001). The HRs (95% CIs) for incident type 2 diabetes for the highest quartile versus referent lowest quartile for serum GGT levels were 3.01 (2.35–3.76) for men and 1.83 (1.30–2.57) for women after adjusting for age, smoking status, daily alcohol intake (g/day), regular exercise, family history of diabetes, and log-transformed LDL-cholesterol, creatinine, and aminotransferase levels.ConclusionIn conclusion, high levels of GGT were found to be associated with increased risk of Mets in both men and women and the positive associations were stronger in men than in women.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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Fig. 1