Rate of tarsal and metatarsal bone mineral density change in adults with diabetes mellitus and peripheral neuropathy: a longitudinal study

Journal of Foot and Ankle Research

Research

Hyo-Jung Jeong¹  Mary K. Hastings²  Nicholas J. Youmans²  Rachana S. Vaidya²  Paul K. Commean²  Jennifer A. Zellers²  Ling Chen²  Alexa York² 

[1] Marquette University, Milwaukee, WI, USA;University of Wisconsin-Milwaukee, Milwaukee, WI, USA;Washington University School of Medicine, MSC 8502-66-1101, 4444 Forest Park Avenue, 63108, St. Louis, MO, USA;

关键词: Foot;    Ankle;    Orthopedics;    Endocrinology;    Computed tomography;    Calcaneus;    Bone loss;   

DOI  :  10.1186/s13047-023-00606-2

 received in 2022-10-03, accepted in 2023-01-26,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundIn people with diabetes (DM) and peripheral neuropathy (PN), loss of bone mineral density (BMD) in the tarsals and metatarsals contribute to foot complications; however, changes in BMD of the calcaneal bone is most commonly reported. This study reports rate of change in BMD of all the individual bones in the foot, in participants with DM and PN. Our aim was to investigate whether the rate of BMD change is similar across all the bones of the foot.MethodsParticipants with DM and PN (n = 60) were included in this longitudinal cohort study. Rate of BMD change of individual bones was monitored using computed tomography at baseline and 6 months, 18 months, and 3–4 years from baseline. Personal factors (age, sex, medication use, step count, sedentary time, and PN severity) were assessed. A random coefficient model estimated rate of change of BMD in all bones and Pearson correlation tested relationships between personal factor variables and rate of BMD change.ResultsMean and calcaneal BMD decreased over the study period (p < 0.05). Individual tarsal and metatarsal bones present a range of rate of BMD change (-0.3 to -0.9%/year) but were not significantly different than calcaneal BMD change. Only age showed significant correlation with BMD and rate of BMD change.ConclusionThe rate of BMD change did not significantly differ across different foot bones at the group level in people with DM and PN without foot deformity. Asymmetric BMD loss between individual bones of the foot and aging may be indicators of pathologic changes and require further investigation.Trial registrationMetatarsal Phalangeal Joint Deformity Progression—R01. Registered 25 November 2015, https://clinicaltrials.gov/ct2/show/NCT02616263

【 授权许可】

CC BY   
© The Author(s) 2023

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