Effect of erythromycin on mortality and the host response in critically ill patients with sepsis: a target trial emulation

Critical Care

Research

Lonneke A. van Vught¹  Tom D. Y. Reijnders¹  Hessel Peters-Sengers¹  Fabrice Uhel²  Tom van der Poll³  Martijn M. Stuiver⁴  Olaf L. Cremer⁵  Marcus J. Schultz⁶  Marc J. M. Bonten⁷ 

[1] Center for Experimental and Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands;Center for Experimental and Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands;AP-HP, Hôpital Louis Mourier, DMU ESPRIT, Médecine Intensive-Réanimation, 92700, Colombes, France;Université de Paris, UFR de Médecine, 75018, Paris, France;INSERM U1151, CNRS UMR 8253, Institut Necker-Enfants Malades, 75015, Paris, France;Center for Experimental and Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands;Division of Infectious Diseases, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;Department of Epidemiology and Data Science, Amsterdam Public Health, Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, The Netherlands;Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, The Netherlands;Department of Intensive Care Medicine, and Laboratory of Experimental Intensive Care and Anesthesiology (LEICA), Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, The Netherlands;Mahidol-Oxford Tropical Medicine Research Unit (MORU), Mahidol University, Bangkok, Thailand;Nuffield Department of Medicine, University of Oxford, Oxford, UK;Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands;Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands;

关键词: Sepsis;    Critically ill;    Macrolides;    Erythromycin;    Immunomodulation;    Propensity score;    Target trial;    Mortality;   

DOI  :  10.1186/s13054-022-04016-x

 received in 2022-03-11, accepted in 2022-05-01,  发布年份 2022

来源: Springer

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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