Frailty and its combined effects with lifestyle factors on cognitive function: a cross-sectional study

BMC Geriatrics

Research

Yike Yan¹  Huan Guo¹  Fangqing Li¹  Chenming Wang¹  Lei Zheng¹  Xin Guan¹  Shiru Hong¹ 

[1] Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, 430030, Wuhan, Hubei, China;

关键词: Frailty;    Mini-mental state examination;    Cognitive function;    Lifestyles;   

DOI  :  10.1186/s12877-023-03761-0

 received in 2022-08-22, accepted in 2023-01-19,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundFrailty describes an age-related state of deterioration in biological function. This study aimed to investigate the association between frailty and cognitive function and its combined effects with lifestyles.MethodsA total of 3,279 participants from the Dongfeng-Tongji (DFTJ) cohort were tested the cognitive function by using the Chinese version of Mini-mental State Examination (MMSE). Frailty was evaluated based on a 35-item frailty index (FI). Frailty status was dichotomized into robust (FI < 0.15) and frail (FI ≥ 0.15). Multivariate generalized linear regression models and logistic regression models were used to estimate the associations of frailty with MMSE score and cognitive impairment. We also analysed the modification and combined effects of lifestyle factors, including smoking status, drinking status, and regular physical exercise, on the above associations.ResultsFI was significantly associated with lower MMSE score [β (95%Cl) = -0.28 (-0.43, -0.13)] and cognitive impairment [OR (95%Cl) = 1.19 (1.04, 1.35)]. The association of frailty status with MMSE were found to be stronger among ever smokers [β(95%Cl) = -1.08 (-1.64, -0.51)] and physical inactive individuals [β(95%Cl) = -1.59 (-2.63, -0.54)] while weaker or not significant among never smokers [β(95%Cl) = -0.30 (-0.62, 0.01)] and physical active individuals [β(95%Cl) = -0.37 (-0.65, -0.08))]. There were significant combined effects of frailty status with unhealthy lifestyles including smoking, alcohol drinking, and physical inactive on cognitive impairment.ConclusionsFrailty was associated with cognitive impairment among Chinese middle-aged and elderly people, while smoking cessation and regular physical exercise could attenuate the above associations, which highlight the potential preventive interventions.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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