Cardiopulmonary, Functional, Cognitive and Mental Health Outcomes Post-COVID-19, Across the Range of Severity of Acute Illness, in a Physically Active, Working-Age Population

Sports Medicine - Open

Original Research Article

Rebecca Chamley¹  David A. Holdsworth¹  Edward D. Nicol²  Andrew Houston³  Samantha May³  Daniel Mills³  Dominic Dewson³  Oliver O’Sullivan⁴  Peter Ladlow⁵  James Mitchell⁶  Alexander N. Bennett⁷  Robert M. Barker-Davies⁸  Mark Cranley⁹  Edward Sellon^1,10  Cheng Xie^1,10  Nick P. Talbot^1,11  Kayleigh Pierce^1,12  Joseph Mulae^1,13  Jon Naylor^1,13  Oliver J. Rider^1,14 

[1] Academic Department of Military Medicine, Birmingham, UK;Oxford University Hospitals NHS Foundation Trust, Oxford, UK;Academic Department of Military Medicine, Birmingham, UK;Royal Brompton Hospital, London, UK;Academic Department of Military Rehabilitation (ADMR), Defence Medical Rehabilitation Centre (DMRC) Stanford Hall, LE12 5QW, Loughborough, UK;Academic Department of Military Rehabilitation (ADMR), Defence Medical Rehabilitation Centre (DMRC) Stanford Hall, LE12 5QW, Loughborough, UK;Academic Unit of Injury, Recovery and Inflammation Sciences, University of Nottingham, Nottingham, UK;Academic Department of Military Rehabilitation (ADMR), Defence Medical Rehabilitation Centre (DMRC) Stanford Hall, LE12 5QW, Loughborough, UK;Department for Health, University of Bath, Bath, UK;Academic Department of Military Rehabilitation (ADMR), Defence Medical Rehabilitation Centre (DMRC) Stanford Hall, LE12 5QW, Loughborough, UK;Metabolic Neurology, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK;Academic Department of Military Rehabilitation (ADMR), Defence Medical Rehabilitation Centre (DMRC) Stanford Hall, LE12 5QW, Loughborough, UK;National Heart and Lung Institute, Imperial College London, London, UK;Academic Department of Military Rehabilitation (ADMR), Defence Medical Rehabilitation Centre (DMRC) Stanford Hall, LE12 5QW, Loughborough, UK;School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK;Defence Medical Rehabilitation Centre (DMRC), Stanford Hall, Loughborough, UK;Oxford University Hospitals NHS Foundation Trust, Oxford, UK;Oxford University Hospitals NHS Foundation Trust, Oxford, UK;Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK;Oxford University Hospitals NHS Foundation Trust, Oxford, UK;Royal Centre for Defence Medicine, Birmingham, UK;Royal Centre for Defence Medicine, Birmingham, UK;University of Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK;Department of Cardiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK;

关键词: Coronavirus disease 2019;    Long Covid;    Post-COVID-19 syndrome;    Cardiopulmonary exercise testing;    Outcomes;   

DOI  :  10.1186/s40798-023-00552-0

 received in 2022-01-31, accepted in 2023-01-13,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe COVID-19 pandemic has led to significant morbidity and mortality, with the former impacting and limiting individuals requiring high physical fitness, including sportspeople and emergency services.MethodsObservational cohort study of 4 groups: hospitalised, community illness with on-going symptoms (community-symptomatic), community illness now recovered (community-recovered) and comparison. A total of 113 participants (aged 39 ± 9, 86% male) were recruited: hospitalised (n = 35), community-symptomatic (n = 34), community-recovered (n = 18) and comparison (n = 26), approximately five months following acute illness. Participant outcome measures included cardiopulmonary imaging, submaximal and maximal exercise testing, pulmonary function, cognitive assessment, blood tests and questionnaires on mental health and function.ResultsHospitalised and community-symptomatic groups were older (43 ± 9 and 37 ± 10, P = 0.003), with a higher body mass index (31 ± 4 and 29 ± 4, P < 0.001), and had worse mental health (anxiety, depression and post-traumatic stress), fatigue and quality of life scores. Hospitalised and community-symptomatic participants performed less well on sub-maximal and maximal exercise testing. Hospitalised individuals had impaired ventilatory efficiency (higher VE/V̇CO2 slope, 29.6 ± 5.1, P < 0.001), achieved less work at anaerobic threshold (70 ± 15, P < 0.001) and peak (231 ± 35, P < 0.001), and had a reduced forced vital capacity (4.7 ± 0.9, P = 0.004). Clinically significant abnormal cardiopulmonary imaging findings were present in 6% of hospitalised participants. Community-recovered individuals had no significant differences in outcomes to the comparison group.ConclusionSymptomatically recovered individuals who suffered mild-moderate acute COVID-19 do not differ from an age-, sex- and job-role-matched comparison population five months post-illness. Individuals who were hospitalised or continue to suffer symptoms may require a specific comprehensive assessment prior to return to full physical activity.

【 授权许可】

CC BY   
© Crown 2023

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