Waterhouse-Friderichsen syndrome following a dog bite in an asplenic patient: case report and review of the literature

International Journal of Emergency Medicine

Case Report

Giorgio Berlot¹  Ariella Tomasini¹  Silvia Zanchi¹  Edoardo Moro¹  Sara Mohamed²  Eleonora de Bellis²  Maurizio Pinamonti³ 

[1] Department of Anesthesia and Intensive Care, Azienda Sanitaria Universitaria Integrata Di Trieste, 34149, Trieste, Italy;Department of Hematology, Azienda Sanitaria Universitaria Integrata Di Trieste, Trieste, Italy;Department of Pathology, Azienda Sanitaria Universitaria Integrata Di Trieste, Trieste, Italy;

关键词: Waterhouse-Friderichsen syndrome;    Septic shock;    Disseminated intravascular coagulation;    Capnocytophaga canimorsus;   

DOI  :  10.1186/s12245-023-00483-3

 received in 2022-12-16, accepted in 2023-02-12,  发布年份 2023

来源: Springer

【 摘 要 】

The Waterhouse-Friderichsen syndrome represents a critical condition characterized by a septic shock associated with a disseminated intravascular coagulation causing the plugging of the microvascular network virtually all organs and systems, including the skin, the kidneys, the liver, and adrenal glands; the mortality rate is elevated, and survivors often must undergo multiple limb amputations. Here, we describe the uncommon case of an asplenic patient who developed this syndrome after a superficial wound caused by a dog bite causing an initial infection due to Capnocytophaga canimorsus that is part of the normal oral microbiome of pets. The clinical and pathological findings and the current and future therapeutic options are reviewed and discussed.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 5

Fig. 5