A retrospective analysis for the management of oromaxillofacial invasive mucormycosis and systematic literature review

BMC Oral Health

Research

Parekejiang Pataer¹  Zhong-cheng Gong¹  Bo Shao¹  Chang Fang¹  Chen-xi Li² 

[1] Department of Oral and Maxillofacial Oncology and Surgery, The First Affiliated Hospital of Xinjiang Medical University, School/Hospital of Stomatology, Xinjiang Medical University, Stomatological Research Institute of Xinjiang Uygur Autonomous Region, No.137 Liyushan South Road, 830054, Ürümqi, People’s Republic of China;Department of Oral and Maxillofacial Oncology and Surgery, The First Affiliated Hospital of Xinjiang Medical University, School/Hospital of Stomatology, Xinjiang Medical University, Stomatological Research Institute of Xinjiang Uygur Autonomous Region, No.137 Liyushan South Road, 830054, Ürümqi, People’s Republic of China;Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, 430022, Wuhan, People’s Republic of China;

关键词: Mucormycosis;    Therapeutic regimen;    Maxillofacial area;    Systematic review;   

DOI  :  10.1186/s12903-023-02823-4

 received in 2022-11-30, accepted in 2023-02-17,  发布年份 2023

来源: Springer

【 摘 要 】

PurposeMucormycosis is a type of fatal infectious disease, rarely involved in the oromaxillofacial region. This study aimed to describe a series of 7 cases with oromaxillofacial mucormycosis and to discuss the epidemiology, clinical features, and treatment algorithm thereof.MethodologySeven patients in the author’s affiliation have been treated. They were assessed and presented as per their diagnostic criteria, surgical approach, and mortality rates. Reported cases of mucormycosis originally happened in craniomaxillofacial region were synthesized through a systematic review so as to better discuss its pathogenesis, epidemiology, and management.ResultsSix patients had a primary metabolic disorder, and one immunocompromised patient had a history of aplastic anemia. The criteria for a positive diagnosis of invasive mucormycosis were based on clinical presentation of signs and symptoms, and a biopsy for microbiological culture and histopathologic analysis. Each patient used antifungal drugs and five of them also underwent surgical resection at the same time. Four patients died due to the unregulated spread of mucormycosis, and one patient died owing to her main disease.ConclusionsAlthough uncommon in clinical practice setting, mucormycosis should be of great concern in oral and maxillofacial surgery, due to the life-threatening possibility of this disease. The knowledge of early diagnosis and prompt treatment is of utmost importance for saving lives.

【 授权许可】

CC BY   
© The Author(s) 2023

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