Role of foetal kidney size on kidney function in childhood: the born in bradford cohort renal study

BMC Nephrology

Research

John Wright¹  Dagmar Waiblinger¹  Dan Mason¹  Robin F Jeffrey¹  Rafaq Azad¹  Richard JM Coward²  Ho M Yuen³  Paul J Roderick³  Simon DS Fraser⁴  Nida Ziauddeen⁴  Nisreen A Alwan⁵ 

[1] Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK;Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK;School of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, UK;School of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, UK;NIHR Applied Research Collaboration Wessex, Southampton, UK;School of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, UK;NIHR Applied Research Collaboration Wessex, Southampton, UK;NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK;

关键词: foetal development;    kidney volume;   

DOI  :  10.1186/s12882-023-03077-6

 received in 2022-09-26, accepted in 2023-02-01,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundFoetal and early childhood development contributes to the risk of adult non-communicable diseases such as hypertension and cardiovascular disease. We aimed to investigate whether kidney size at birth is associated with markers of kidney function at 7–11 years.MethodsFoetal kidney dimensions were measured using ultrasound scans at 34 weeks gestation and used to derive kidney volume (cm3) in 1802 participants in the Born in Bradford (BiB) birth cohort. Blood and urine samples were taken from those who participated in the BiB follow-up at 7–11 years (n = 630) and analysed for serum creatinine, cystatin C, urea, and urinary albumin to creatinine ratio (ACR), protein to creatinine ratio (PCR) and retinol binding protein (RBP). Estimated glomerular filtration rate (eGFR) was calculated using Schwartz creatinine only and combined with cystatin C, and cystatin C only Zappitelli and Filler equations. Linear regression was used to examine the association between foetal kidney volume and eGFR, ACR, PCR and blood pressure, unadjusted and adjusted for confounders.ResultsKidney volume was positively associated in adjusted models with eGFR calculated using Schwartz combined (0.64 ml/min diff per unit increase in volume, 95% CI 0.25 to 1.02), Zappitelli (0.79, 95% CI 0.38 to 1.20) and Filler (2.84, 95% CI 1.40 to 4.28). There was an association with the presence of albuminuria but not with its level, or with other urinary markers or with blood pressure.ConclusionFoetal kidney volume was associated with small increases in eGFR in mid-childhood. Longitudinal follow-up to investigate the relationship between kidney volume and markers of kidney function as children go through puberty is required.

【 授权许可】

CC BY   
© The Author(s) 2023

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