Estimating the economic burden of respiratory syncytial virus infections in infants in Vietnam: a cohort study

BMC Infectious Diseases

Research

Thanh Uyen Pham¹  Anh Tuan Tran¹  Nguyen Thanh Nhan Le¹  Thi Ngoc Kim Le¹  Thi Thanh Hai Nguyen¹  Van Quang Pham¹  Quang Tung Thai¹  Lien Anh Ha Do²  Kim Mulholland³  An Nguyen⁴  Clinton Pecenka⁵  Elisabeth Vodicka⁵  Minh Thang Cao⁶  Thu Ngoc Nguyen⁶ 

[1] Children’s Hospital 1, Ho Chi Minh City, Vietnam;New Vaccine Group, Murdoch Children’s Research Institute, 50 Flemington Road, 3051, Parkville, Melbourne, Australia;Department of Pediatrics, The University of Melbourne, Melbourne, Australia;New Vaccine Group, Murdoch Children’s Research Institute, 50 Flemington Road, 3051, Parkville, Melbourne, Australia;Department of Pediatrics, The University of Melbourne, Melbourne, Australia;London School of Hygiene and Tropical Medicine, London, UK;PATH, Hanoi, Vietnam;PATH, Seattle, USA;Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam;

关键词: Respiratory syncytial virus;    Lower respiratory tract infections;    Direct cost;    Indirect cost;    Cost of illness;   

DOI  :  10.1186/s12879-023-08024-2

 received in 2022-09-08, accepted in 2023-01-23,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundLittle information is available on the costs of respiratory syncytial virus (RSV) in Vietnam or other low- and middle-income countries. Our study estimated the costs of LRTIs associated with RSV infection among children in southern Vietnam.MethodsWe conducted a prospective cohort study evaluating household and societal costs associated with LRTIs stratified by RSV status and severity among children under 2 years old who sought care at a major pediatric referral hospital in southern Vietnam. Enrollment periods were September 2019–December 2019, October 2020–June 2021 and October 2021–December 2021. RSV status was confirmed by a validated RT-PCR assay. RSV rapid detection antigen (RDA) test performance was also evaluated. Data on resource utilization, direct medical and non-medical costs, and indirect costs were collected from billing records and supplemented by patient-level questionnaires. All costs are reported in 2022 US dollars.Results536 children were enrolled in the study, with a median age of 7 months (interquartile range [IQR] 3–12). This included 210 (39.2%) children from the outpatient department, 318 children (59.3%) from the inpatient respiratory department (RD), and 8 children (1.5%) from the intensive care unit (ICU). Nearly 20% (105/536) were RSV positive: 3.9 percent (21/536) from the outpatient department, 15.7% (84/536) from the RD, and none from the ICU. The median total cost associated with LRTI per patient was US$52 (IQR 32–86) for outpatients and US$184 (IQR 109–287) for RD inpatients. For RSV-associated LRTIs, the median total cost per infection episode per patient was US$52 (IQR 32–85) for outpatients and US$165 (IQR 95–249) for RD inpatients. Total out-of-pocket costs of one non-ICU admission of RSV-associated LRTI ranged from 32%-70% of the monthly minimum wage per person (US$160) in Ho Chi Minh City. The sensitivity and the specificity of RSV RDA test were 88.2% (95% CI 63.6–98.5%) and 100% (95% CI 93.3–100%), respectively.ConclusionThese are the first data reporting the substantial economic burden of RSV-associated illness in young children in Vietnam. This study informs policymakers in planning health care resources and highlights the urgency of RSV disease prevention.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 5

Fig. 2