Newly discovered roles of triosephosphate isomerase including functions within the nucleus

Molecular Medicine

Mini-Review

Tracey D. Myers¹  Michael J. Palladino¹ 

[1] Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, 15261, Pittsburgh, PA, USA;Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, 15261, Pittsburgh, PA, USA;Center for Neuroscience, University of Pittsburgh School of Medicine, 15213, Pittsburgh, PA, USA;

关键词: Triosephosphate isomerase (TPI);    TPI deficiency;    Genetics;    Glycolysis;    Metabolism;    Moonlighting;    Gene sharing;   

DOI  :  10.1186/s10020-023-00612-x

 received in 2022-10-27, accepted in 2023-01-20,  发布年份 2023

来源: Springer

【 摘 要 】

Triosephosphate isomerase (TPI) is best known as a glycolytic enzyme that interconverts the 3-carbon sugars dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P). TPI is an essential enzyme that is required for the catabolism of DHAP and a net yield of ATP from anaerobic glucose metabolism. Loss of TPI function results in the recessive disease TPI Deficiency (TPI Df). Recently, numerous lines of evidence suggest the TPI protein has other functions beyond glycolysis, a phenomenon known as moonlighting or gene sharing. Here we review the numerous functions ascribed to TPI, including recent findings of a nuclear role of TPI implicated in cancer pathogenesis and chemotherapy resistance.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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