Smart nanoparticles and microbeads for interventional embolization therapy of liver cancer: state of the art

Journal of Nanobiotechnology

Review

Yi Hou¹  Yinghua Zou²  Qi Yang³  Zhao Chen³  Lei Kang³  Sitong Wu⁴  Kevin Fan⁵  Weibo Cai⁵ 

[1] College of Life Science and Technology, Beijing University of Chemical Technology, 100029, Beijing, China;Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, 100034, Beijing, China;Department of Nuclear Medicine, Peking University First Hospital, 100034, Beijing, China;Department of Nuclear Medicine, Peking University First Hospital, 100034, Beijing, China;Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, 100034, Beijing, China;Departments of Radiology and Medical Physics, University of Wisconsin, 53705, Madison, WI, USA;

关键词: Microspheres;    Nanoparticles;    Transarterial chemoembolization;    Multifunctional;    Degradable;    Hepatocellular carcinoma;   

DOI  :  10.1186/s12951-023-01804-7

 received in 2023-01-04, accepted in 2023-02-01,  发布年份 2023

来源: Springer

【 摘 要 】

The process of transcatheter arterial chemoembolization is characterized by the ability to accurately deliver chemotherapy drugs with minimal systemic side effects and has become the standard treatment for unresectable intermediate hepatocellular carcinoma (HCC). However, this treatment option still has much room for improvement, one of which may be the introduction of nanomaterials, which exhibit unique functions and can be applied to in vivo tumor imaging and therapy. Several biodegradable and multifunctional nanomaterials and nanobeads have recently been developed and applied in the locoregional treatment of hepatocellular cancer. This review explores recent developments and findings in relation to micro-nano medicines in transarterial therapy for HCC, emerging strategies to improve the efficacy of delivering nano-based medicines, and expounding prospects for clinical applications of nanomaterials.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 3