Functional targeted therapy for glioma based on platelet membrane-coated nanogels

Cancer Nanotechnology

Research

Siyun Lei¹  Yimin Yang¹  Fei Kong¹  Weide Xu¹  Qin Li²  Ke Hao³  Yaling Wang³  Jinglan Shen³  Yi Zhang³  Zhen Wang³  Kaiqiang Li³  Lina Peng³  Wei Yang⁴  Lingling Wu⁵ 

[1] Center for Laboratory Medicine, Allergy Center, Department of Transfusion Medicine, Zhejiang Provincial People’s Hospital People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, 310014, Hangzhou, China;Center for Laboratory Medicine, Allergy Center, Department of Transfusion Medicine, Zhejiang Provincial People’s Hospital People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, 310014, Hangzhou, China;Department of Clinical Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, 621000, Mianyang, People’s Republic of China;Center for Laboratory Medicine, Allergy Center, Department of Transfusion Medicine, Zhejiang Provincial People’s Hospital People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, 310014, Hangzhou, China;Key Laboratory of Biomarkers and In Vitro Diagnosis Translation of Zhejiang Province, 310063, Hangzhou, Zhejiang, China;Department of Biophysics, and Department of Neurosurgery of the First Affiliated Hospital, Zhejiang University School of Medicine, 31058, Hangzhou, China;Women’s Hospital, School Of Medicine, Zhejiang University, 310014, Hang Zhou, People’s Republic of China;

关键词: Glioma;    Blood–brain barrier;    Biomimetic drug delivery system;    Vasculogenic mimicry;    Platelet membrane;    Nanogel;   

DOI  :  10.1186/s12645-023-00167-w

 received in 2022-11-23, accepted in 2023-02-15,  发布年份 2023

来源: Springer

【 摘 要 】

Glioma treatment remains a challenge owing to unsatisfactory targeted chemotherapy, where the blood–brain barrier (BBB) hinders the efficient uptake of therapeutics into the brain. Vasculogenic mimicry (VM) formed by invasive glioma cells negatively affects the treatment of glioma. Herein, we developed a targeted biomimetic drug delivery system comprising a doxorubicin-loaded platelet membrane-coated nanogel (DOX@PNGs). The nanogels provide great redox/pH dual responsiveness, while the platelet membrane (PLTM) promotes stability and circulation time. In vitro cellular uptake and in vivo imaging experiments demonstrated that the DOX@PNGs delivery system could penetrate the BBB, target gliomas, and destruct VM. DOX@PNGs increased drug penetration and prolonged mouse survival time during the treatment of orthotopic gliomas. These results indicate this biomimetic drug delivery system to be promising for glioma treatment and may be clinically translated in the future.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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