期刊论文详细信息
Cell Communication and Signaling
Exosomal transmission of viruses, a two-edged biological sword
Review
Narges Mardi1  Mohammad Nouri1  Morteza Milani1  Amir Zarebkohan2  Sanya Haiaty3  Halimeh Mobarak4  Reza Rahbarghazi5 
[1] Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Stem Cell Research Center, Tabriz University of Medical Sciences, Imam Reza St., Golgasht St., Tabriz, Iran;Stem Cell Research Center, Tabriz University of Medical Sciences, Imam Reza St., Golgasht St., Tabriz, Iran;Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;
关键词: Viruses;    Exosomes;    Shared signaling pathways;    Transmission;    Infection;   
DOI  :  10.1186/s12964-022-01037-5
 received in 2022-09-25, accepted in 2022-12-28,  发布年份 2022
来源: Springer
PDF
【 摘 要 】

As a common belief, most viruses can egress from the host cells as single particles and transmit to uninfected cells. Emerging data have revealed en bloc viral transmission as lipid bilayer-cloaked particles via extracellular vesicles especially exosomes (Exo). The supporting membrane can be originated from multivesicular bodies during intra-luminal vesicle formation and autophagic response. Exo are nano-sized particles, ranging from 40–200 nm, with the ability to harbor several types of signaling molecules from donor to acceptor cells in a paracrine manner, resulting in the modulation of specific signaling reactions in target cells. The phenomenon of Exo biogenesis consists of multiple and complex biological steps with the participation of diverse constituents and molecular pathways. Due to similarities between Exo biogenesis and virus replication and the existence of shared pathways, it is thought that viruses can hijack the Exo biogenesis machinery to spread and evade immune cells. To this end, Exo can transmit complete virions (as single units or aggregates), separate viral components, and naked genetic materials. The current review article aims to scrutinize challenges and opportunities related to the exosomal delivery of viruses in terms of viral infections and public health.1usDPZGy_VWRKyt7iwDMqLVideo Abstract

【 授权许可】

CC BY   
© The Author(s) 2023

【 预 览 】
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