Major risk factors for Streptococcus dysgalactiae subsp. equisimilis bacteremia: a population-based study

BMC Infectious Diseases

Research

Viivi Nevanlinna¹  Reetta Huttunen¹  Sari Rantala¹  Janne Aittoniemi²  Tiina Luukkaala³ 

[1] Department of Internal Medicine, Tampere University Hospital, Elämänaukio, Kuntokatu 2, 33520, Tampere, Finland;Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland;Fimlab Laboratories, Tampere, Finland;Research, Development and Innovation Center, Tampere University Hospital, Tampere, Finland;Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland;

关键词: Streptococcus dysgalactiae;    Group C streptococci;    Group G streptococci;    Bacteremia;    Risk factor;    Obesity;   

DOI  :  10.1186/s12879-023-07992-9

 received in 2022-10-17, accepted in 2023-01-09,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundStreptococcus dysgalactiae subspecies equisimilis is a human pathogen causing severe invasive infections. Detailed information on S. dysgalactiae subsp. equisimilis bacteremia and especially of predisposing factors are lacking. The purpose of the study is to investigate the risk factors of S. dysgalactiae subsp. equisimilis bacteremia compared to the general population in Finland.MethodsWe retrospectively reviewed all patients older than 18 years with S. dysgalactiae subsp. equisimilis bacteremia in the Pirkanmaa health district from August 2015 to July 2018. The risk factors for S. dysgalactiae subsp. equisimilis bacteremia were investigated with respect to the normal population in Finland using the Finhealth study data provided by the Finnish institute for health and welfare. The study group was matched with the Finhealth study by age and sex.ResultsAltogether 230 cases of S. dysgalactiae subsp. equisimilis bacteremia were detected. The medical records of 217 episodes of S. dysgalactiae subsp. equisimilis bacteremia (involving 211 patients) were available for analysis. Obesity was a statistically significant risk factor for S. dysgalactiae subsp. equisimilis bacteremia (Odds Ratio 2.96 [95% CI 2.22–3.96]). Diabetes and coronary artery disease were also associated with an increased risk of S. dysgalactiae subsp. equisimilis bacteremia (OR 4.82 [95% CI 3.62–6.42]) and (OR 3.03 [95% CI 2.18–4.19]).ConclusionsWe found obesity, diabetes, and coronary artery disease to be associated with an increased risk for S. dysgalactiae subsp. equisimilis bacteremia. These results provide an increased understanding of risk factors for S. dysgalactiae subsp. equisimilis bacteremia.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

41116_2022_35_Article_IEq492.gif