Unintended impact of COVID-19 pandemic on the rate of catheter related nosocomial infections and incidence of multiple drug resistance pathogens in three intensive care units not allocated to COVID-19 patients in a large teaching hospital

BMC Infectious Diseases

Research

Elham Shafiee¹  Mansoor Masjedi¹  Farid Zand¹  Naeimehossadat Asmarian¹  Reza Nikandish¹  Hedayatollah Vakili²  Azita Tabatabaei Esfehani³  Fatemeh Azadi³  Anahita Sanaei Dashti⁴  Golnar Sabetian⁵ 

[1] Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;

关键词: Nosocomial infection (NI);    Intensive care unit (ICU);    Ventilator associated pneumonia (VAP);    Central line associated blood stream infection (CLABSI);    Catheter-associated urinary tract infections (CAUTI);    Multiple drug resistance (MDR);    COVID-19;   

DOI  :  10.1186/s12879-022-07962-7

 received in 2022-02-25, accepted in 2022-12-21,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundThe prevalence of resistant hospital infections in the intensive care unit (ICU) increases mortality and antibiotic resistance. COVID-19 pandemic may have unintended impact on nosocomial infections (NI) and the prevalence of resistant microorganism.MethodologyThe present non-interventional study was performed by a pre and a post survey each lasting 8 months before (March–October 2019) and after (March–October 2020) the onset of COVID-19 pandemic in three ICU’s, not allocated to COVID-19 patients, in Nemazee Hospital, Shiraz, Iran. The rates of the following nosocomial infections were compared at pre- and post-pandemic period: ventilator associated pneumonia (VAP), central line associated blood stream infection (CLABSI), catheter-associated urinary tract infections (CAUTI) and incidence of multiple drug resistance (MDR) pathogens.ResultsPre-pandemic and pandemic incidence of VAP was 23.5 and 17.2 cases per 1000 device-days, respectively; an absolute decrease of 27%. The main reason for the decrease in the rate of VAP during the pandemic was a significant decrease in the rate of VAP caused by Acinetobacter baumannii; from 39 to 17% in total VAP episodes. The rate of VAP associated with other microorganisms remained relatively unchanged from 14.2 cases in pre-pandemic period to 14.3 cases per 1000 MV-days during the pandemic (P = 0.801). Pre-pandemic incidence of CLABSI was 7.3 cases and, in pandemic period, was 6.5 cases per 1000 device-days (IRR = 0.88, 95% CI  0.43–1.73, P = 0.703). Pre-pandemic incidence of CAUTI was 2 and in pandemic period, was 1.4 cases per 1000 device-days (IRR = 0.70, 95% CI  0.22–1.98, P = 0.469).ConclusionThe results of the present study showed a decrease in the incidence of VAP in critically ill non-COVID-19 patients during the pandemic compared to before the pandemic, especially regarding Acinetobacter baumannii.

【 授权许可】

CC BY   
© The Author(s) 2023

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